Gene transfer and cardiovascular disease
نویسندگان
چکیده
منابع مشابه
BRIEF REVIEWS Gene Transfer and Cardiovascular Disease
Through the introduction of foreign DNA into somatic cells, the aim of gene therapy is to correct or prevent disorders caused by the absence or malfunction of genes within a diseased individual. Expression of recombinant genes at specific sites within the vasculature can provide insights into vascular biology and potential treatments for various cardiovascular disorders. In our studies, we have...
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Adenoviral gene transfer is a valuable tool in molecular biology research. In order to be an efficient and safe vector, adenovirus structure and infection mechanism as well as molecular biology of the used transgene need to be well studied. The aim of this study was to evaluate the role of adenovirus as a gene transfer vector from several perspectives. Adenovirus uses receptor-mediated endocyto...
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The last decade has seen substantial advances in the development of gene therapy strategies and vector technology for the treatment of a diverse number of diseases, with a view to translating the successes observed in animal models into the clinic. Perhaps the overwhelming drive for the increase in vascular gene transfer studies is the current lack of successful long-term pharmacological treatm...
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Gene therapy is defined as the transference of nucleic acids to somatic cells of an individual resulting in a therapeutic effect (Yla-Herttuala & Martin, 2000). Among the advantages of gene therapy over the existent modalities of treatment are: the selective treatment of affected tissues, the possibility of using locally endogenous proteins in cases where its systemic application would incur in...
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ژورنال
عنوان ژورنال: Trends in Cardiovascular Medicine
سال: 1991
ISSN: 1050-1738
DOI: 10.1016/1050-1738(91)90053-h